AAA<\/strong> (ailesel akdeniz ate\u015fi<\/strong>, familial mediterenian fever<\/strong>, FMF<\/strong>) genellikle Akdeniz \u00fclkeleri halklar\u0131nda (daha \u00e7ok T\u00fcrk, Arap, \u0130srailli ve Ermenilerde) g\u00f6r\u00fclen, otozomal resesif ge\u00e7i\u015fli genetik (kal\u0131t\u0131msal) bir hastal\u0131kt\u0131r. Birbirinden ba\u011f\u0131ms\u0131z iki ayr\u0131 klinik tablosu vard\u0131r.<\/p>\n 2- Gen\u00e7 ya\u015fta bile b\u00f6brek yetmezli\u011fine neden olabilen b\u00f6brek amiloidozu. (b\u00f6brekte amiloid birikmesine ba\u011fl\u0131 yetmezlik). Belirtiler gen\u00e7 ya\u015fta ortaya \u00e7\u0131kar, hastal\u0131\u011f\u0131n ba\u015flang\u0131c\u0131; hastalar\u0131n yar\u0131s\u0131nda 10 ya\u015f\u0131ndan \u00f6ncedir.<\/p>\n AAA tan\u0131s\u0131 klinik bulgular, ailede bu hastal\u0131\u011f\u0131n varl\u0131\u011f\u0131n\u0131n bilinmesi, muayene ve (\u00f6zellikle atak esnas\u0131nda yap\u0131lan) laboratuvar incelemeleri ile konur. Kesin bir sonu\u00e7 vermese de baz\u0131 vakalarda genetik ara\u015ft\u0131rma i\u015fe yarayabilir ve tan\u0131 koymada faydal\u0131 olabilir.<\/p>\n Amiloidoz daha \u00e7ok hi\u00e7 tedavi g\u00f6rmemi\u015f AAA hastalar\u0131nda g\u00f6r\u00fcl\u00fcr. Bu durum idrarda protein \u00e7\u0131k\u0131\u015f\u0131n\u0131n basit bir idrar tahliliyle saptanmas\u0131yla hastal\u0131\u011f\u0131n erken d\u00f6nemlerinde te\u015fhis edilir.<\/p>\n Bu hastal\u0131\u011f\u0131n tedavisinde kol\u015fisin kullan\u0131l\u0131r. Bu ilac\u0131n dozu g\u00fcnde 1-2mg d\u0131r ve s\u00fcrekli kullan\u0131lmal\u0131d\u0131r. \u0130la\u00e7 AAA i\u00e7in tart\u0131\u015fmas\u0131z yararl\u0131d\u0131r; (s\u00fcrekli kullan\u0131m\u0131 halinde) hastalar\u0131n \u00e7o\u011funda atak olu\u015fmas\u0131n\u0131, hemen, hemen t\u00fcm hastalarda da amiloidozun ba\u015flamas\u0131n\u0131 \u00f6nler. Ne var ki b\u00f6brek \u015fikayeti olmayan hastalarda ve kol\u015fisin kullanmaya ba\u015flamadan \u00f6nce amiloidoz geli\u015fmi\u015f olan AAA li hastalarda da amiloidoza rastlan\u0131lmaktad\u0131r.<\/p>\n Kol\u015fisin\u2019in ataklar\u0131 ve amiloidoz olu\u015fumunu nas\u0131l \u00f6nledi\u011fi bilinmemektedir. Fakat \u015fu ger\u00e7ek bilinmektedir ki; kol\u015fisin kullanmas\u0131na ra\u011fmen s\u0131k atak ge\u00e7iren fakat amiloidozun duraklat\u0131ld\u0131\u011f\u0131 hastalarda, ilac\u0131n FMF ataklar\u0131n\u0131 \u00f6nlemedeki etkisi ile amiloid (amiloidozda anormal olarak b\u00f6brekte biriken bir madde) yap\u0131m\u0131n\u0131 durdurucu etkisi aras\u0131nda hi\u00e7bir ili\u015fki bulunmamaktad\u0131r.<\/p>\n Kol\u015fisin tedavisi AAA hastalar\u0131 i\u00e7in en g\u00fcvenli ve uygun se\u00e7enektir.<\/p>\n Sebebi yap\u0131lan ara\u015ft\u0131rmalara ra\u011fmen bulunamam\u0131\u015f k\u0131s\u0131rl\u0131k, AAA li ki\u015filerde normal ki\u015filere g\u00f6re daha fazlad\u0131r. Amiloidozu olan AAA hastalar\u0131na gebe kalmamalar\u0131 \u00f6nerilir. \u0130lac\u0131 kullanan hastalar\u0131n \u00e7ocuklar\u0131nda kol\u015fisinin herhangi bir teratojenik etkisine rastlanmamas\u0131na ra\u011fmen, t\u00fcm AAA li gebelerde (bebekte ila\u00e7tan dolay\u0131 geli\u015febilecek herhangi bir sakatl\u0131\u011f\u0131n vs tesbiti i\u00e7in) amniosentez yap\u0131l\u0131r. Ayr\u0131ca bebekte kromozom anomalisi olup olmad\u0131\u011f\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in genetik analiz yap\u0131lmal\u0131d\u0131r. Bu tetkik anne karn\u0131ndaki bebekten amnion s\u0131v\u0131s\u0131 al\u0131narak yap\u0131l\u0131r.<\/p>","protected":false},"excerpt":{"rendered":" Ailesel Akdeniz Ate\u015fi AAA (ailesel akdeniz ate\u015fi, familial mediterenian fever, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[400],"tags":[464,465,466,467,468],"class_list":["post-491","post","type-post","status-publish","format-standard","hentry","category-romatizmal-hastaliklar","tag-aaa","tag-ailesel-akdeniz-atesi","tag-ailesel-akdeniz-atesi-tedavisi","tag-familial-mediterenian-fever","tag-fmf"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/posts\/491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/comments?post=491"}],"version-history":[{"count":1,"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/posts\/491\/revisions"}],"predecessor-version":[{"id":10753,"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/posts\/491\/revisions\/10753"}],"wp:attachment":[{"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/media?parent=491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/categories?post=491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/turanuslu.net\/es\/wp-json\/wp\/v2\/tags?post=491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n1- Ani ba\u015flayan ve k\u0131sa s\u00fcreli kar\u0131n, g\u00f6\u011f\u00fcs veya eklemlerde a\u011fr\u0131 ile birlikte ate\u015f olmas\u0131.<\/p>\n